Vinyl Chloride Carcinogen

Vinyl chloride vc is a human carcinogen known to undergo metabolism by cytochrome p450 2e1 cyp2e1 to reactive intermediates that can cause oncogene and tumor suppressor gene mutations and that are further metabolized by acetaldehyde dehydrogenase aldh2 and glutathione s transferases gsts to non mutagenic end products.

Vinyl chloride carcinogen. Vinyl chloride iarc monographs on the evaluation of carcinogenic risks to humans volume 100f. For practical purposes vinyl fluoride should be considered to act similarly to the human carcinogen vinyl chloride national toxicology program 14th report on carcinogens reasonably anticipated to be human carcinogens learn more about the topics in this list in the ntp s report on carcinogens at https ntp niehs. It is made softer and more flexible by the addition of phthalates and can contain traces of chemicals like bisphenol a bpa. Vinyl chloride is a mutagen having clastogenic effects which affect lymphocyte chromosomal structure.

It can be formed when other substances such as trichloroethane trichloroethylene and tetrachloroethylene are broken down. Epa s integrated risk information system iris is a human health assessment program that evaluates information on health effects that may result from exposure to environmental contaminants. Vinyl chloride is used primarily 95 in the manufacture of polyvinyl chloride pvc which comprises about 12 of the total use of plastic. World health organization 2012.

Also available online. It is a manufactured substance that does not occur naturally. Vinyl chloride is classified as group 1 carcinogen by the iarc meaning it is seen as a definite cause of cancer in humans. The international agency for research on cancer has determined that vinyl chloride is carcinogenic to people and epa has determined that vinyl chloride is a human carcinogen.

Where risks occur the main route of occupational exposure to vinyl chloride is by inhalation which occurs primarily in vinyl chloride pvc plants and in pvc processing plants including packaging storage and handling of. Department of health and human services has determined that vinyl chloride is a known carcinogen. Vinyl chloride is a group 1 human carcinogen posing elevated risks of rare angiosarcoma brain and lung tumors and malignant haematopoeitic lymphatic tumors. Polyvinyl chloride pvc is a solid plastic material made from vinyl chloride.

Pvc is used to make pipes polyvinyl flooring and siding hoses cable coatings medical devices and plumbing and automotive parts. It burns easily and it is not stable at high temperatures. It has a mild sweet odor.