Vinyl Chloride And Hcc

Vinyl chloride is an organochloride with the formula h 2 c chcl that is also called vinyl chloride monomer vcm or chloroethene this colorless compound is an important industrial chemical chiefly used to produce the polymer polyvinyl chloride pvc.

Vinyl chloride and hcc. However no data about the prevalence of such mutations in vc associated hccs are available recent data indicate k ras 2 mutations induce p16 methylation accompanied by inactivation of. Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s. Vinyl chloride is extensively used in the plastic industry and it is a well recognized risk factor for development of asl which is an extremely rare neoplasia when not associated with vc exposure. In vc associated las mutations of the k ras 2 gene have been reported.

The results from the. The most up to date and most comprehensive analy ses is a pooled analyses of cohorts of vcm workers from. In 2007 the international agency for research on cancer established the association of vcm with hepatocellular carcinoma hcc though o. Objective to evaluate mortality risks of angiosarcoma of the liver asl primary hepatocellular carcinoma hcc and other cancers among 9951 men employed between 1942 and 1972 at 35 us vinyl chloride vc or polyvinyl chloride plants followed for mortality through 31 december 2013.

Recently the international agency for research on cancer has also included vc among the definite causes of hcc 1 but this assumption is not. Vinyl chloride is a chlorinated hydrocarbon occurring as a colorless highly flammable gas with a mild sweet odor that may emit toxic fumes of carbon dioxide carbon monoxide hydrogen chloride and phosgene when heated to decomposition. In fact the assessment of vinyl chloride as a cause of hcc is complicated because most studies do not have histological or other definitive clinical information to discriminate hcc from asl and or secondary neoplasms. Vinyl chloride is primarily used to make polyvinyl chloride to manufacture plastics.

Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s. 2 after the first report of three cases of asl in subjects employed in the manufacture of pvc resins 15 epidemiological. Methods smr and time dependent cox proportional hazards analyses were used to evaluate mortality risks by. Vinyl chloride and hcc.

The results from the two large multicenter studies and the pooled meta analysis are presented in table 2. Vinyl chloride and hcc the most up to date and most comprehensive analyses is a pooled analyses of cohorts of vcm workers from plants in the usa and europe 41. Plants in the usa and europe 41.